Fruit flies light the way for scientists to pinpoint genetic changes that spell cancer

Fruit flies light the way for scientists to pinpoint genetic changes that spell cancer

Monday, July 30, 2012

By studying fruit flies, scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have successfully devised a fast and cost-saving way to uncover genetic changes that have a higher potential to cause cancer. With this new approach, researchers will now be able to rapidly distinguish the range of genetic changes that are causally linked to cancer (i.e. "driver" mutations) versus those with limited impact on cancer progression. This research paves the way for doctors to design more targeted treatment against the different cancer types, based on the specific cancer-linked mutations present in the patient. This study published in the prestigious journal Genes & Development could help advance the development of personalised medicine in cancer care and treatment.

The era of genomic sequencing has generated an unparalleled wealth of information on the complexity of genetic changes that occur as cancer develops and progresses. "Many genetic changes arise in cancer cells and changes continue to accumulate during the progression of disease to metastatic cancer [1]. The current challenge is to understand which of the many genetic changes are important drivers of disease progression" said Dr. Stephen Cohen, Principal Investigator at IMCB and team leader of this paper.

Though very different in many ways, fruit flies and humans share similarities in a remarkable two-thirds of their genomes. That is to say, many of the genes found in humans are also present in the flies. Similarly, various signalling pathways involved in tumour formation are also well conserved from fruit flies to humans. In fact, previous studies have shown that about 75 percent of known human disease genes have a recognisable match in the genome of fruit flies [2].

Leveraging on their genetic similarities, Dr H?ctor Herranz, a post-doctorate from the Dr Cohen's team developed an innovative strategy to genetically screen the whole fly genome for "cooperating" cancer genes. On their own, these are the genes that appear to be harmless and have little or no impact on cancer. But in fact, they cooperate with other cancer genes, so that the combination causes aggressive cancer, which neither would cause alone.

In this study, the team was specifically looking for genes that could cooperate with EGFR [3] "driver" mutation, a genetic change commonly associated with breast and lung cancers in humans. SOCS5, reported in this paper, is one of the several new "cooperating" cancer genes to be identified through this innovative approach. Most of these new-found genes have yet to be identified as cancer genes in human or mouse models.

Said Mr Xin Hong, a PhD student and the co-first author of this paper, "We were very surprised by our finding because this it the first time that the Socs gene family is found to be linked to cancer. Previously it has only been associated with immunological disorders."

Dr. Cohen added, "Though these studies are in the early stages, they are very promising. Already, there are indications that levels of SOCS5 expression are reduced in breast cancer, and patients with low levels of SOCS5 have poor prognosis."

The IMCB team is preparing to explore the use of SOCS5 as a biomarker in diagnosis for cancer.

Said Professor Wanjin Hong, Executive Director of IMCB, "This study sheds light on the complexities of cancer genetics and paves the way to accelerate development of personalised medicine in cancer care. It is a fine examples of how powerful genetic approach using the fly model can reveal molecular mechanisms underlying human cancer. More importantly, it shows how fundamental research can have far-reaching applications for potential clinical benefits."

###

[1] Cancer metastasis is the rapid and often fatal spread of cancer cells from the primary tumour to other parts of the body, and is often the leading cause of death by cancer.

[2] Reiter, LT; Potocki, L; Chien, S; Gribskov, M; Bier, E (2001). "A Systematic Analysis of Human Disease-Associated Gene Sequences In Drosophila melanogaster" Genome Research 11(6):1114-1125 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC311089/?tool=pmcentrez

[3]Epidermal growth factor receptor (EGFR) is a cell surface protein that binds epidermal growth factor binds, causing cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so that these cancer cells may divide excessively in the presence of epidermal growth factor

Agency for Science, Technology and Research (A*STAR), Singapore: http://www.a-star.edu.sg

Thanks to Agency for Science, Technology and Research (A*STAR), Singapore for this article.

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Source: http://www.labspaces.net/122136/Fruit_flies_light_the_way_for_scientists_to_pinpoint_genetic_changes_that_spell_cancer_

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French parliament votes in sexual harassment law

PARIS (AP) ? France's parliament on Tuesday approved legislation that makes sexual harassment a crime, addressing problems many say have existed for decades in the country.

The new law sets three levels of harassment, with the most serious ? in cases where the harasser has authority over the victim, the victim is younger than 15 years old, or multiple people carry out the harassment ? punishable by up to three years in prison.

The National Assembly passed the law after the Senate voted earlier in the day. Its passage comes more than two months after a court struck down the previous statute, saying it was too vague and failed to protect women.

The legislation covers offenses in universities, the housing market and job interviews. Single acts of sexual blackmail will be considered sexual harassment, whereas previously only repeated acts were.

In the United States, sexual harassment is a civil offense usually punishable by fines.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-07-31-France-Sexual%20Harassment/id-1d1fd081288e45ea8eaab273dc8efbf4

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Reasons For Purchasing Your Desired Magazine Online | Internet ...

Businesses Online | Internet and Businesses Online | * Written by khalil huseni | Monday, 30 July 2012 01:44 | Word Count: 436

Buying a magazine of your choice meant, going out and visiting a good number of stores to locate the one that can provide you with the desired magazine of your choice. However with the help of internet, now you can simply place an order for magazine online and can save your time and energy. Internet has been gaining popularity among the people of the developed as well as the developing nations. It has become a solution for anything that one wants to know or needs. You can easily find answers for all your queries and much more. With the ecommerce technology widely used by many, shopping or purchasing anything online has been gaining more popularity for umpteen benefits that it offers to the purchasers. A lot of people are keen readers and are required to purchase different magazines of their choice very frequently. To get their favourite magazine they need to move out and visit a number of stores to check the availability of the particular magazine that they are looking for.

The process of visiting so many stores and find the one which has the magazine of your choice was a tedious and time consuming activity. These stores have limited stock which is bound to get sold quickly and if you do not reach on time, you are ought to lose the opportunity of getting that magazine. However, there is nothing to worry now as you can easily purchase your preferred magazine online. This option is extremely easy as you firstly are not required to visit different stores to get the desired magazine. There are innumerable sites that you can log on to and order the subscription of any magazine of your choice.

Purchasing a magazine online is less troublesome as you only need to access the internet and place an order by staying in the comforts of your premises. If your office keeps you busy and every time you miss on going to the local store to get your magazine, then you have nothing to bother about now. You can purchase the magazine with the help of your computer or laptop right from your office. Placing an order for the magazine via internet is not only easy and convenient, but also saves a lot of time. The only thing required is to log on to the trusted site and place an order by a click. These sites are equipped with an effective system of technology, security and delivery backups. These features make it possible for these sites to deliver the product within the promised period and thus, provides you with fast and superior services.

Dobazaar is a UAE based online bookstore that offers all types of Magazine Online. Buy Magazine in Dubai and get free Delivery at your doorstep

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Author of this article: khalil huseni.

khalil huseni joined FAFY - Free Article For You on Tuesday, 10 July 2012.

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You Can Find Great Health Insurance For Less! | larun4victimsrights ...

So just what is going on with commercial health insurance in this day and age? With everything else going on in your life, it can be nearly impossible to keep track of the latest trends and information.

If you jump out of planes for a living, or go rock climbing on the weekends, make sure and disclose that when you are purchasing insurance. You will more than likely pay a higher amount for your insurance. However, if you do not tell them that information they can choose not to pay out for your claim if it was a result of those activities. Be honest, even if it will cost you more.

When you?re admitted to a hospital, expect a great deal of documentation from your health insurance company as well as all the other people and groups who may have treated you. Although it can be bewildering, please make the effort to thread your way through the insurance bill details so that you can be completely sure you understand what you were charged for. This way if something was not covered to your satisfaction, you will be able to identify it and call it out to the health insurance company for follow-up.

Use the resources available to you. There are several websites online that allow you to privately input your family?s information, and use it to compare health insurance policies and prices. This can be extremely beneficial to those who may not have the time to shop around for this information on their own.

Let your medical insurance company know that you are traveling. Some companies will not provide any coverage to you or your family in a foreign country unless you purchase extra coverage. You may not end up needing it, but it is always better to be safe than sorry when you are traveling.

A key health insurance tip is to always be certain to have your most recent health insurance card in your wallet. Carrying an older card puts you at risk of having incorrect coverage information used when your care provider determines billing amounts. Making sure you have a current card handy increases the likelihood of accurate billing and helps prevent unpleasant financial surprises.

If you make a lot of money in your own small business, it is probably cheaper for you to get private health insurance. There will be no influence on the cost of your premiums from the amount of your income, so it won?t go up or down as your earnings do.

Avoid risks! If you must purchase your own health insurance policy, it is a good idea to live a healthy lifestyle and refrain from engaging in risky activities. Those who ? do not smoke, drink to excess, and who maintain a healthy weight ? can enjoy lower health insurance premiums. People who engage in risky behavior or hold jobs that are considered risky may not be able to get health insurance or their premiums may be higher.

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Learn all of the different options available to you with health insurance. With all of the different plans and choices, choosing health insurance can get really confusing. Plus, you might miss an important option because you didn?t even know to look for it. Use one of the online health insurance quote providers and request quotes. The service is anonymous, and it?s the quickest way to see all of the options offered by different health insurers and compare policy offerings against each other so you can get the most health insurance coverage for your dollar spent.

Health Insurance For Individuals

Many people who are self-employed face a quandary about health insurance. They know they need to be covered in case of health emergencies, and yet the cost of health insurance for individuals is so high as to be prohibitive for many. Some people get around this by buying major medical coverage only. This type of policy has a very high deductible, covers no preventive care ? however, it will cover situations where the person will require admission to a hospital.

In conclusion, it is definitely difficult to stay on top of all of the latest tips and tricks coming out about health insurance. To make matters worse, information is constantly changing ? making it nearly impossible to be an expert unless you make it a point to keep yourself up to date. Hopefully you found this article interesting, informative, and were able to learn a couple of new things.

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Source: http://www.larun4victimsrights.com/?p=222

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Solid Health and fitness Tips For A Busy Mom ?

The topic of exercise addresses many areas. Workout plans, eating properly and getting the correct amount of sleeping are common elements of an exercise software. You are able to build your very own system to get a lean body, your lifestyle or your appearance. This article aspires to offer for your place to start to hitting your fitness goals.

Give any bench you?re planning to exercise on an examination prior to using it. Use your thumb to click downward and test the bench support. If you are wooden or steel that may be underneath the table, get yet another chair.

The fundamentals of weight training: Create muscular mass by at the same time undertaking less repetitions and picking up more weight. Begin with choosing a muscle group. Do a warm-up established by strength training that are super easy to elevate. Decide on weight load you can do around 15 to 20 reps with. The second established must entail weight loads for which you are only able to perform 6-8 reps. Add a minimum of 5 kilos of additional excess weight, then recurring your third set up.

Do you wish to boost your energy as well as your rate? Begin education like they actually do in Kenya. Kenyans coach by starting slow to the initially 3rd of the operate. You may then gradually enhance your speed through the run. By the center of your operate, you will end up operating at your regular pace. Manage in a quicker pace during the last 3rd. By regularly accomplishing this, you?ll practical experience substantial enhancements in your energy and velocity immediately.

Drive-ups are an oldie-but-goodie to get the jiggle away from your triceps. An excellent angle at close to 45 degrees together with your palms is much better process. When you do pushups this way, you?ll hold the triceps focused and increased more efficiently.

If you want to boost your persistence for health and fitness, purchase a multiple-30 days gym commitment. The shame you may sense by not utilizing the membership will with a little luck get you to visit more frequently than you usually would. This should be carried out as a final holiday resort, mainly in case you have a challenging time pushing you to ultimately go to.

It is often useful to count in the opposite direction if you are completing repeating exercises. You are able to stay motivated by discovering how lots of people are remaining so you won?t cease within your initiatives.

When you get hurt then attempt to work out all of your body. Biceps and triceps and hip and legs are independent for each other. If someone is harmed, keep working one other and you will be able to keep your level of fitness with the trauma. This is because of connected muscle mass materials.

If you wind up spraining a muscle, it is essential that you place ice-cubes on the region right away. That may continue to keep any inflammation and redness down. Elevating the sprain to ensure suitable circulation of blood is likewise crucial. Don?t put the an ice pack on the skin directly. Try wrapping it within a cloth very first.

Get the entire family associated with your exercise strategy. To help keep your household motivated, permit every single member to decide on an exercise action that you can do collectively. Have a sign of everyone?s daily health and fitness activities to trace who is accomplishing what. Hopefully, everybody will see an issue that works for them.

An exercise journal can really help inspire you to stick with your exercise program, particularly in the essential early days. Your exercise journal songs your final results so it helps determine your successes. Deal with physical fitness as being a daily life-transforming aim.

Start with the lesser weight equipment and work your path approximately the important kinds. Your smaller muscles will get tired before your greater kinds, and it likewise can make a great deal of feeling to use small dumbbells well before utilizing big kinds. It is because if you are working out large ones the smaller types might strain.

Fitness is difficult or generally exciting, however if you create a program that matches your likes and dislikes and find a way to keep encouraged, you will absolutely appreciate training. No person will be able to handle fitness without having finding out how to properly get it done initially. All that you should do is commence and you may get the help you require.

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Territory Sales Manager/sr. Territory Sales Manager ... - Jobs in India

Posted by: DLF Pramerica Life Insurance company Ltd
Posted date: 30-Jul Job Description:Job Profiles:- Manage the business relationship between DPLI and Identified Business Partner(s) Productivity of the Channel Partner as per the set business norms. Managing Partner Sales Training and Business Processes Support day to day operation of the sales Managing sales and sale related activity in the channel within the state . Manage sourcing, processing and issuance, post issuance customer issues (if any) Manage financials of relationship, including support meeting of financial targets, sales promotion activities, support timely and correct commission reconciliation Facilitate and anchor ongoing training and skills development for channels and employees including new hires at channels. Ensure adherence to all company policies and processes at channel partner end. Ensure adherence of code of conduct set by IRDA and Life Insurance Council. Ensure conformation to all financial and administrative systems. Ensure Compliance to all statutory &amp regulatory norms.

Desired Candidate ProfileShould be comfortable working in rural market Should be comfortable in front line sales profile

Experience Required: 2 to 6

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Judge says Arizona's abortion ban can take effect

PHOENIX (AP) ? Arizona's ban on abortions starting at 20 weeks of pregnancy is poised to take effect this week as scheduled after a federal judge ruled Monday that the new law is constitutional.

U.S. District Judge James Teilborg said the statute may prompt a few pregnant women who are considering abortion to make the decision earlier. But he said the law is constitutional because it doesn't prohibit any women from making the decision to end their pregnancies.

The judge also wrote that the state provided "substantial and well-documented" evidence that an unborn child has the capacity to feel pain during an abortion by at least 20 weeks.

Republican Gov. Jan Brewer signed the measure into law in April, making Arizona one of 10 states to enact types of 20-week bans.

Arizona's ban, set to take effect Thursday, prohibits abortions starting at 20 weeks of pregnancy except in medical emergencies. That is a change from the state's current ban at viability, which is the ability to survive outside the womb and which generally is considered to be about 24 weeks. A normal pregnancy lasts about 40 weeks.

The New York-based Center for Reproductive Rights and another group filed a notice that they would be appealing Teilborg's decision to the 9th U.S. Circuit Court of Appeals.

"Today's decision casts aside decades of legal precedent, ignoring constitutional protections for reproductive rights that have been upheld by the United States Supreme Court for nearly 40 years and threatening women's health and lives," said Nancy Northup, the center's president and CEO.

Maricopa County Attorney Bill Montgomery, who was sued as part of the challenge, said there was no telling whether the appeals court would prevent the law from taking effect. Commenting on Monday's decision, Montgomery said, "I thought it was sound legal reasoning and reached the appropriate conclusion."

Brewer also lauded the ruling, saying in a statement that it protects women and children.

Teilborg held a hearing Wednesday on a request from abortion-rights groups that he temporarily block the law's enforcement.

The groups' lawyer said during the hearing that the ban crosses a clear line on what U.S. Supreme Court rulings permit, and it intrudes on women's health decisions at a key point in pregnancy. Montgomery argued the state Legislature was justified in enacting the ban to protect the health of women and to shield fetuses from pain.

A second Arizona anti-abortion law enacted earlier this year also faces a court challenge. That law would bar public funding for non-abortion health care provided by abortion doctors and clinics.

The anti-abortion laws are among many approved by Arizona's Republican-led Legislature. The other laws include restrictions on clinic operations, mandates for specific disclosures and a prohibition on a type of late-term abortion.

Attorney Janet Crepps of the Center for Reproductive Rights argued at Wednesday's hearing that under Supreme Court decisions starting with the 1973 Roe vs. Wade ruling that legalized abortion, states can only regulate how abortions are performed, not ban them, before a fetus is viable.

Montgomery said that not implementing the 20-week ban would doom fetuses that might be saved due to advances in medicine.

While North Carolina has long had a 20-week ban, Nebraska in 2010 was the first state to recently enact one. Five more states followed in 2010: Alabama, Idaho, Indiana, Kansas and Oklahoma.

Along with Arizona, Georgia and Louisiana approved 20-week bans this year, though Georgia's law doesn't take effect until 2013.

The Center for Reproductive Rights said none of the 20-week bans have so far been blocked by courts.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-07-30-Arizona%20Abortion%20Ban/id-8942d4dde9ca4a738498271423c7ec35

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Thyroid: Omnilife | Revista Women's Health

The thyroid is a gland in the neck below the Adam?s apple. It weighs about 30 grams (one ounce) and is shaped like a butterfly, with two lateral lobes that are joined by wrapping the trachea. It belongs to the endocrine system, which is a set of organs and tissues that produce, store and discharge-chemicals-hormones in the bloodstream.

It consists of numerous follicles, or sacs, which houses the thyroid hormones. These hormones contain a high concentration of iodine in fact, almost eighty percent of iodine in the body lodges in the thyroid.

When there is a shortage of iodine in the diet causes the overgrowth of the gland known as goiter. Iodine deficiency in children inhibits the production of hormones and, therefore, retards their physical, mental and sexual, which is called cretinism.

Many women lost their babies in the first trimester of pregnancy, with the common factor of successive abortions without knowing why. Over time, you start to gain weight despite exercising and watch your diet, often feel cramps in the legs and increases sensitivity to cold.

With blood tests and ultrasound of the thyroid gland revealed a condition of a condition known as lymphocytic thyroiditis or Hashimoto?s disease.

Most people do not pay much attention to your thyroid, but the declining health makes us see the importance of this gland.

What is the role of thyroid hormones? And help us omnilife products?

As the accelerator is used to regulate the speed of a vehicle, the thyroid hormones regulate the rate of metabolism, ie, the chemical activity of the cells that generate energy and new tissues.

Therefore contribute to normal tissue growth and repair, influence heart rate and maintain the body temperature and muscle energy production.

Thyroid hormones perform other important tasks such as helping the liver to remove excess blood triglycerides and LDL, or bad cholesterol.

Cholesterol is transported into the bile and ends up being eliminated in the feces. Thus, the decreased levels of these hormones can cause an increase in bad cholesterol and lower good cholesterol.

What regulates the thyroid?

The hypothalamus is the region of the brain that control the thyroid. When it detects a decrease in hormones, it sends a signal to another gland, the pituitary gland or pituitary at the base of the brain just above the palate, to release a thyroid-stimulating hormone (known as TSH).

In cases of suspected malfunction of the gland, can be diagnosed by measuring its state blood levels of TSH and thyroid hormones.

The nutrients present in the products omnilife, stimulate the pituitary gland and it begins to release hormones TSH, also boost the immune system and regulate the body?s physiological functions.

Thyroid dysfunction may be due to a diet low in iodine, physical or mental stress, birth defects, infections, diseases (usually with immunological) or side effects from medical treatments. Goitre, or enlargement of the gland, there may be a diffuse or nodular.

Although usually benign, you should always consult with a specialist, it could be something more serious, like a cancerous tumor.

Thyroid disorders are usually two: hyperthyroidism (excessive production of hormones) and hypothyroidism (low activity), and can be studied for years in a gradual and asymptomatic, with no one noticing. Obviously, it is a diagnosis while the disease is in its early stages.

The most common disorders of the thyroid are Hashimoto?s disease and bass. Both are immune in nature, since the own immune system attacks the body?s cells as if they were intruders.

Hashimoto?s disease is six times more common in women than in men and usually results in hypothyroidism. Moreover, severe disease is eight times more common in women than in men and usually generates hyperthyroidism.

Many people are aware of the importance of the thyroid, despite its small size. So take care of his own: make sure your food is healthy and include the necessary iodine, avoid chronic stress and do your best to stay healthy.

Among the symptoms that occur due to thyroid disorders are:

Hyperthyroidism: nervousness, weight loss, palpitations, diarrhea, irregular menstruation, irritability, anxiety, mood swings, eyes bulging, muscle weakness, insomnia and hair thin and brittle.

Hypothyroidism: lack of energy and drowsiness, weight gain, hair loss, constipation, cold intolerance, irregular menstruation, depression, hoarseness, memory loss and fatigue.

Proper nutrition helps to prevent thyroid disorders. Does feeding the iodine it needs your body? Marine products provide a good amount. However, the proportion of iodine in vegetables varies depending on the chemical composition of the soil where they grow, and in the case of meat, the animals eat grass.

To compensate for the absence of iodine in food, some governments require that salt is iodized. Selenium is also very important.

Omnilife products containing the nutritional balance needed to maintain or restore the health of your thyroid.

Source: http://revistawomenshealth.com/diseases/thyroid/thyroid-omnilife.html?utm_source=rss&utm_medium=rss&utm_campaign=thyroid-omnilife

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100 Day Sun Devil Football Countdown To Kickoff, #32: The Keith Poole Touchdown Photo

Today's entry on the Countdown to Kickoff is perhaps the single greatest image in the history of Arizona State Sun Devil football.

It's so awesome, we'll shut up and let everyone revel in it's splendor.

See all the previous entries on House of Sparky's 100 day football countdown here.

Follow me on Twitter @BDenny29 and like House of Sparky on Facebook

Source: http://www.houseofsparky.com/2012/7/29/3081693/keith-poole-asu-arizona-touchdown

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To find Home Improvement & Appliances related information quickly ...

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Source: http://boomarking.com/World-News/browse-by-category-top--home-improvement-appliances-page-1/

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zonal pacific: tv 3 news: Timeshare @ TradeWinds ? Travel - blog*spot

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Source: http://zonal-pacific.blogspot.com/2012/07/tv-3-news-timeshare-tradewinds-travel.html

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Real Estate Video Marketing Competition | The Web Internetarian ...

• Real estate marketing and advertising video these days leaves little or no room for a shaky, word wasting, time sucking video that most people are shooting with their mobile devices, flip video, or digital cameras.? No longer will a virtual tour of walking up the stairs while huffing and puffing, out of breathe, while showing off the bannister and
• Delicious
• Pin It

Source: http://bradsdomain.com/real-estate-video-marketing-competition/

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Tech titans face off in court over iPhone, iPad

SAN FRANCISCO (AP) ? Two tech titans will square off in federal court Monday in a closely watched trial over control of the U.S. smart phone and computer tablet markets.

Apple Inc. filed a lawsuit against Samsung Electronics Co. last year alleging the world's largest technology company's smartphones and computer tablets are illegal knockoffs of its popular iPhone and iPad products. The Cupertino-based company is demanding $2.5 billion in damages, an award that would dwarf the largest patent-related verdict to date.

Samsung counters that Apple is doing the stealing and that some of the technology at issue ? such as the rounded rectangular designs of smart phones and tablets ? has been industry standards for years.

The U.S. trial is just the latest skirmish between the two over product designs. A similar trial began last week, and the two companies have been fighting in courts in the United Kingdom and Germany. The case is one of some 50 lawsuits among myriad telecommunications companies jockeying for position in the burgeoning $219 billion market for smartphones and computer tablets.

In the United States, U.S. District Judge Lucy Koh in San Jose last month ordered Samsung to pull its Galaxy 10.1 computer tablet from the U.S. market pending the outcome of the trial, though the judge barred Apple attorneys from telling the jurors about the ban.

"That's a pretty strong statement from the judge and shows you what she thinks about some of Apple's claims," said Bryan Love, a Santa Clara University law professor and patent expert. Love said that even though the case will be decided by 10 jurors, the judge has the authority to overrule their decision if she thinks they got it wrong.

"In some sense the big part of the case is not Apple's demands for damages but whether Samsung gets to sell its products," said Mark A. Lemley, a Stanford Law School professor and director of the Stanford Program in Law, Science, and Technology.

Lemley also said a verdict in Apple's favor could send a message to consumers that Android-based products such as Samsung's are in legal jeopardy. A verdict in Samsung's favor, especially if it prevails on its demands that Apple pay its asking price to certain transmission technology it controls, could lead to higher-priced Apple products.

Lemley and other legal observers say it's rare that a patent battle with so much at stake doesn't settle short of a trial. Court-ordered mediation sessions attended by Apple's chief executive Tim Cook and high-ranking Samsung officials failed to resolve the legal squabble, leading to a highly technical trial of mostly expert witnesses opining on patent laws and technology. Cook is not on the witness list and is not expected to testify during what is expected to be a four week-trial.

Lemley, Love and others say it also appears that Apple was motivated to file the lawsuit, at least in part, by its late founder's public avowals that companies using Android to create smartphones and other products were brazenly stealing from Apple. To that end, Samsung's attorneys made an unsuccessful pitch to have the jury hear excerpts from Steve Jobs' authorized biography.

"I will spend my last dying breath if I need to, and I will spend every penny of Apple's $40 billion in the bank, to right this wrong, I'm going to destroy Android, because it's a stolen product," Jobs is quoted as saying in Walter Isaacson's book "Steve Jobs" published in November. "I'm willing to go thermonuclear war on this."

But the judge barred those statements in a ruling earlier this month.

"I really don't think this is a trial about Steve Jobs," Koh said.

In court papers filed last week, each company laid out its legal strategy in so-called "trial briefs."

Apple lawyers argue there is almost no difference between Samsung's products and Apple's and that the South Korean company's internal documents show it copied Apple's iconic designs and its interface.

"Samsung once sold a range of phones and a tablet of its own design," Apple lawyers argue in their documents filed Wednesday. "Now Samsung's mobile devices not only look like Apple's iPhone and iPad, they use Apple's patented software features to interact with the user."

Samsung denies the allegation and counter-charges that Apple copied its iconic iPhone from Sony. Samsung lawyers noted that the company has been developing mobile phones since 1991 and that Apple jumped into the market only in 2007.

"In this lawsuit, Apple seeks to stifle legitimate competition and limit consumer choice to maintain its historically exorbitant profits," Samsung lawyers wrote in their trial brief also filed Wednesday. "Android phones manufactured by Samsung and other companies ? all of which Apple has also serially sued in numerous forums worldwide ? offer consumers a more flexible, open operating system with greater product choices at a variety of price points as an alternative to Apple's single, expensive and closed-system devices."

"Between 2005 and 2010 alone, Samsung invested $35 billion in research and development relating to telecommunications technology, with over 20,000 engineers worldwide dedicated to telecommunications research and development," Samsung's lawyers wrote.

"One thing that is notable is that this trial is happening at all," said Love, the Santa Clara law professor and patent expert. He said that in an industry such as this where so many companies hold so many vital patents needed by all players, lawsuits are viewed as toying with "mutually assured destruction" and that most disputes are solved through "horse trading" and agreements to share intellectual property and royalties.

Source: http://news.yahoo.com/tech-titans-face-off-court-over-iphone-ipad-154701805--finance.html

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Her Favourite Food: Smithy's Restaurant & Wine Bar

Where:??King's Cross

Cuisine:? Modern European

This has to be King?s Cross?s best kept secret, and a very good one at that.
Smithy?s is in the centre of London but has an intimate feel of a local about it. Only those lucky enough to be in the know wine and dine here and it?s obvious they appreciate the place.


As a family run business, Smithy?s has great character about it, but this also stems from the rich history of the place. Over a hundred years ago the building was home to the magnificent shire horses that used to pull the omnibuses on London's streets. Now it sits behind a small non discrete black door down a cobbled secret side street.

Many of the original features have been kept and they add to the authenticity of the restaurant including a cobbled floor.

With the addition of fairy lights and tables at different levels and intimate corners, Smithy?s has a warm and convivial atmosphere.

Would I want Seconds?

The menu here changes here almost daily and it is designed according to availability of local produce and seasonal variations. As a result there is always something new to try and so always a reason to come back for seconds.

But in addition to the food there is also a large variety of carefully selected wines and ale on offer. In this way Smithy?s caters for a variety of needs from a quick drink or a three-course meal.

Could I afford Seconds?

The cheapest time to eat here is at Lunch. Smithy?s offer a ?Quick Lunch? option between 12pm-3pm were the main course cost ?8.50. The menu is varied so there will be something for vegetarians as well as meat eaters. But come the dinner slot and the prices rise. A main course will cost an average of ?16 -?20 which is expensive for the type of food on offer.

As a result Smithy?s is an affordable and lovely place for a nice atmospheric lunch, and an ideal unique and buzzing bar for evening drinks.

Overall:

3/5

In the evenings Smithy?s becomes more a bar than a restaurant, which is shame because it has the potential to be a very distinctive and successful venue for evening dinning. However I would still recommend a visit, even if it is just for a drink to soak up the atmosphere.

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Source: http://herfavfood.blogspot.com/2012/07/smithys-restaurant-wine-bar.html

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Wine and Food Travel: Cheers! To the official "Wine of the Olympics"

?

In ?the spirit of the 2012 London Olympic Games?which begins in only a few hours, I thought it was only appropriate to move ?off schedule? and share thoughts on a very interesting article related to ?Olympic wines.? ?This year will be the first since 1896 that the Olympic Games have officially named any wines or spirits as ?Official Wines of the Olympic Games.? Wine seems to be a controversial choice of beverage for olympic athletes, but you may also say that about other large sponsorships such as Coco-Cola or McDonald?s. ?All of that said, we all know that as the excitement builds, so does our appetites for watching and celebrating our patriotism, our athletes and the sense of hope as we watch history being made. ?Since we are celebrating, what better way than with ?official spirits? ? Cheers to that, I say!

In my limited research (keep in mind that I have only a few hours before I myself will be planted in front of a 60? screen with a glass in hand), I discovered that some of the ?Official Wines of the Games? are not just promoted because of their country of origin. ?They may actually have something to bragg about. ?An article in ?The Telegraph? showcases of few of Britain?s whites that were found to be quite popular? in places outside of Britain. ?That is the key afterall because anyone can ?toot their own horn? but if others join the orchestra, then you know you?ve got something.

All of this said, if you are thinking of opening a bottle? or two in the spirit of the Olympic games, you may want to honor our hosts and support the ?official Olympic wines?, toast our athletes and enjoy!

?

For more information on Official Olympic Wines, please visit the Official supplier of wines and spirits for the London Olympic Games: Bibendum

Photo credit: messinahofblog (Flickr)

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Source: http://www.wineandfoodtravel.com/wine/cheers-official-wine-olympics/?utm_source=rss&utm_medium=rss&utm_campaign=cheers-official-wine-olympics

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Abrahamson: Games kick off with style

A scene from the "Pandemonium" act of the London Olympics Opening Ceremony, produced by Academy Award-winner Danny Boyle.

LONDON -- Inside the stadium, everyone sang along to "Hey, Jude" with Sir Paul McCartney. Over the city, fireworks boomed out over the Tower Bridge. Around the world, two of every three people watched on television Friday night as the XXX Olympiad got underway, its history to be written over the next 16 days.

The rain mostly held off -- was that an omen portending good for these Games? -- in what has been one of the rainiest summers in British history, London playing host to the Olympics for the third time. It staged the Games in 1908 and again in 1948.

Seven young British torchbearers lit the cauldron -- a tiny flame within a copper petal on the ground that triggered the ignition of more than 200 petals and then converged to form a single "flame of unity." The cauldron is due to be moved to a different place into the stadium during the Games, then disassembled at the close of the Olympics -- meant to evoke a flower that blooms only for a while.

The party-vibe contrast with China, and 2008 -- which opened with the awe-inspiring sound of 2,008 drums, unmistakably signaling the portent of history -- could not have been more dramatic.

As the British Prime Minister, David Cameron, had said in London on Friday, "This is a time of some economic difficulty for the U.K. but look at what we are capable of achieving as a nation, even at a difficult economic time. This is not a a London Games, this is not an England Games, this is a United Kingdom Games."

This is also widely expected to be the Games of U.S. swim stars Michael Phelps and Ryan Lochte; of Jamaican track and field standouts Usain Bolt and Yohan Blake; of the U.S. women's gymnastics team and Japan's Kohei Uchimura, perhaps the best male gymnast of all time.

The ceremony Friday, which ran over into early Saturday morning, underscored the important role that women, and female athletes in particular, seem destined to play at these Games.

For the first time, women from all 204 national Olympic committees will be competing in the Summer Olympics.

In his remarks in the stadium, the president of the International Olympic Committee, Jacques Rogge, said, ?This is a major boost for gender equality.?

Saudi Arabia, Brunei and Qatar had been the final holdouts; the flag-bearer from Qatar, for instance, Bahya Mansour Al Hamad, a shooter, is female.

The 529-member American delegation featured more women, 268, than men, 261 -- a consequence of 40 years of Title IX, the landmark federal law that prohibits discrimination in school and sports.

One of those 268 women, Mariel Zagunis, the gold medal-winning fencer, led the American team into Olympic Stadium -- cheered on by, in part, First Lady Michelle Obama.

In her Twitter feed, one of the female wrestlers on the U.S. team, Kelsey Campbell, said the First Lady offered some advice: "Have fun, try to breathe a little, and win!!!"

Brenda Villa, the U.S. women's water polo star playing in her fourth Olympics, said about the opening ceremony, "You walk in together behind our awesome American flag ? and then you just get this rush of adrenaline and you're, like, 'OK. We're here. It's on. Let's go.' "

Roughly 45 percent of the 10,500 athletes taking part in the London Games will be female. All 26 sports on the Olympic program will feature female competitors. Boxing, at last, will feature female competitors in three weight classes.

Finally, this, after an opening ceremony that saw or heard sheep and chickens; a time trip through the Industrial Age and the Digital Age; a military-jet flyover; the ringing of a big bell; Queen Elizabeth and James Bond; Mary Poppins and Lord Voldemort; Pink Floyd, the Sex Pistols, The Clash; and of course, Sir Paul.

All that ? the show ran long, and still they let McCartney finish, unlike two weeks ago in Hyde Park, when he and Bruce Springsteen had the sound turned off.

With more than 60,000 people singing that sad song, and making it better.

? 2012 NBCUniversal Media, LLC. All rights reserved. Any use, reproduction, modification, distribution, display or performance of this material without NBCUniversal's prior written consent is prohibited.

Source: http://www.nbcolympics.com/news-blogs/2012/its-on-lets-go-the-games-have-begun.html

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Nick Diaz Update: Will Return, Wants Anderson Silva

Like a passing case of the munchies, UFC welterweight contender Nick Diaz's plans to retire seem to have faded, and taking the place of that retirement is a burning desire to face UFC middleweight champ Anderson Silva.? All this is according to his longtime coach, Cesar Gracie, who posted a lengthy statement on the matter over at GracieFighter.

It was only just February when Diaz purportedly turned his back on the sport, a move prompted by his controversial unanimous decision loss to Carlos Condit at UFC 143.??The defeat?came?after a five-round scrap for the UFC Interim Welterweight Championship title, and the bout?saw Condit playing "hit and run" while the Stockton native followed him around and?hurled insults.? Soon after,?it was revealed that?Diaz had tested positive for?marijuana metabolites in a post-fight urinalysis, and the subsequent year-long suspension levied upon him appeared to be the icing on the retirement cake.

Said Gracie:

For the last couple months I've watched Nick begin to frequent the gym more and more.? He's training harder now than he has for many of his fights.? It was obvious that training and fighting is in his DNA.? It is who he is.

This week we had a great talk and he made it clear to me that he is ready to get back in the cage.? Nick Diaz will return.

With interim champ Condit destined to face UFC welterweight champ Georges St. Pierre at UFC 154 in November, who is there for Diaz - an elite,?top-level fighter -?to face that's worthwhile?

As far as future opponents, Nick has stated that he would like to take fights "that matter".? Since GSP will be fighting Condit, he has to look elsewhere.? He will respectfully ask for a fight with Anderson Silva, a fighter he respects and would like to challenge.

Silva's camp has been speaking of a fight with GSP, possibly even at a catchweight.? Nick will take that fight in a minute but has told me that should Silva decide not to drop at all, he will move up to 185lbs to face the Champ.

And there you have it.? Unfortunately, unless Diaz (or, more aptly, his attorneys) can figure out a way around his suspension, ain't nothin' going down 'till February, 2013.? Remember kids, dope is for dopes.? Don't be a dope!

Jim Genia tweets here and wrote this book.? Come at me, bro.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/nick-diaz-return-wants-anderson-silva-000443797--mma.html

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Tyrannosaurs In Mexico

The human history of Mexico is interesting, but after diligent study it can all seem desperately depressing. Between the ruthless Spanish conquest, the bloody civil wars, and the cutthroat politics, Mexico is home to far too much human drama. So let's jump back in time--way back--to when the land was ruled by creatures whose notion of politics was less 'diplomatic maneuvering' and more 'skull full of 8-inch teeth'.

Yes, dinosaurs. They fascinate all of us at some point, regardless of age, gender, or geographic location. Known only from a handful of fossilized remains, dinosaurs are a stark reminder of the incredible age of the Earth, and the immense variety of life that lived and died long before humans came around. They are tantalizing; every new discovery raises more questions than it answers. And no dinosaur is more dramatic or terrifying than the Tyrannosaurus Rex.

This theropod dinosaur lived in western North America during the late Cretaceous period, between 67 and 65 million years ago. They were among the last dinosaurs to exist before the massive K-T extinction event that killed most life on Earth. Back in the Cretaceous, North America was barely recognizable, split in two by a massive inland sea that covered most of the American Midwest. The T-rex had an impressive range, from Alberta all the way down to the northern Mexican states, and it's no wonder; it was one of the largest land-based carnivores in the world. Fossilized specimens measure 40 feet in length, and weight estimates range from five to seven tons.

The Tyrannosaurus Rex is so famous that it almost defies the need for description: it ran on two huge and powerful hind legs, and had a gigantic skull filled with sharp teeth and huge, forward-facing eyes. The small front arms bore powerful claws, and its heavy body was balanced by an impressively bulky tail. The T-Rex was either an apex predator--hunting other carnivorous animals--or a scavenger; debate has raged over the years. But it is known that those teeth were capable of crushing bones, and the forward-facing eyes are still found on predators to this day.

Scientists know more about the Tyrannosaurus Rex than they do most other dinosaurs, in part because they've found several complete fossilized skeletons. This is an incredibly rare event; most dinosaur fossils are small collections of bones. But T-Rex remains have been relatively abundant; some have even contained preserved soft tissue and proteins. Researchers have been able to determine sexual dimorphism, possible cannibalistic tendencies, and even evidence that T-Rexes suffered from parasitic infections. With their intimidating skulls and massive size, it's no wonder that Tyrannosaurus Rex is the most recognizable dinosaur on the planet. If you thought that dinosaurs couldn't possibly have lived in your own backyard, think again; from the wine fields of Sonora to the deserts of Texas, your homestead was once the hunting ground of the Cretaceous Era's most famous predator.

At BookIt.com you will find great travel specials and vacation deals for destinations worldwide. Our helpful guides and travel tips will give you the information you need to make your travel plans a breeze. Book the ideal vacation package for your Mexican getaway. May we suggest Now Jade Riviera Cancun as your next vacation destination?

Source: http://articles.submityourarticle.com/tyrannosaurs-in-mexico-284914

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The Search for the Elusive Chicken Tender | Special Education ...

I?m sure we are not the only parents who struggle to find the foods your child eats while on vacation.? As many of you, we will do what it takes to find something for our son to eat at a restaurant or hotel.? We usually stay at hotel with a timeshare so that we have a kitchen for breakfast and lunch.?

The timeshare properties usually have the nicer pool area; however, the one we stayed at in Arizona it was the?reverse.??We went to Arizona to have some R&R and visit my in-laws.? From California, it?s only a 6 hour drive.? The hotel had a 110 foot waterslide with a 900 foot lazy river.? The hotel was about a mile away and we needed to take a shuttle to get there so going back to the room for lunch was not possible.? The first day of our vacation I made him a peanut butter and jelly sandwich to take to the hotel so that we could use their pool.? The pool area was great; he stayed in the water for hours!? When it came time for lunch, we ordered from the pool bar restaurant and my son pulled out his sandwich.? An hour later, the pool manager came over to us and in a very nice way mentioned for future reference, the hotel doesn?t allow guests to bring food into the pool area.? Yes, I could have brought up the Americans with Disabilities Act and I?m sure he would have allowed us to continue to bring in sandwiches for my son but he was so nice I let it go.

The next day, we went back to the hotel pool; remember I said Arizona; the temperature was now in the triple digits.? So when lunch time came, it was too hot to eat poolside.? My husband went to the hotel restaurant to make sure they had chicken tenders and french fries.? What they had was teriyaki glazed chicken tenders with jasmine rice and vegetables.? He asked if he could just get plain chicken tenders and french fries and the hostess said that it was not on their menu, so we could not.

He found that odd, so he went to the hotel concierge and asked if any of the restaurants in the hotel serve regular chicken tenders and french fries.? She replied of course, room service has them and they control all the food supply in the hotel. His next response was, then why can?t I order chicken tenders in the restaurant.? She said that didn?t make any sense, so she called the chef in the restaurant and he?said no problem.? The chef actually said in the coolest Australian accent, ?I can do that all day long, mate.?

We ended up going to the hotel restaurant a couple of more times because it was in the triple digits and my son couldn?t get enough of the lazy river; so we ate lunch in the hotel as well.? Since, we had a new waiter each time we visited we had to have a long conversation everyday explaining what my son wanted.? Chefs are funny because many of them can?t help themselves to try and make even the most basic kids meal look fancy.? Today?s chicken tenders came out with the french fries covered in chopped parsley flakes to make it look pretty.? Unfortunately we had to ask them to take it back.

The third and last time we went to the hotel restaurant for lunch I started to explain again to the new waiter and he stopped me half way through and said, ?oh you want it room service style, no worries.?? By the way, they came our perfectly so next time I just need to remember the magic words, ?room service style? and it will come out just the way he likes it, plain with no garnish!!

However the search didn?t stop there.? One night my in-laws stayed with my son so we could go to dinner and a movie.? There was a nice complex across from where we stayed that included some unique restaurants.? After we finished dinner, there was still time before the movie began, so we decided to once again search for the elusive chicken tender.? Instead of going into Sephora to shop; we walked up and down the complex, going into every restaurant asking whether they make chicken tenders.? How funny is that?even when our son isn?t with us; he?s not far from our minds!? We stumbled across a nice Italian restuarant?that had french fries?.jackpot, close enough!

Sometimes we never find something my son will eat but we will still go?to the restaurant.? Never fear?.mama always carries a spare PB&J sandwich in those situations and we have never had a restaurant complain to us about it yet!!!!

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Source: http://www.specialeducationadvisor.com/the-search-for-the-elusive-chicken-tender/

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How Email marketing Services May help Businesses? | Marketing

In today?s world, socializing is a good and value effective activity that takes your web business to new levels helping you will enjoy best leads in small time frame.

Social websites optimization and networking happens to be order throughout the day plus its dictating web based business by referral marketing. Social networking optimization and networking has helped many small businesses to grow bigger, and big businesses to guide the world of competitive market in just a few couple of days.

Now, in case you want to you could make your business to excel in the gruesome and competitive online world, primary that you just have to do note is hiring right services of experienced and professional Social websites Agency. Once you have made the right selection, success will happen automatically.

How Would I Be Helped By Social websites Services?

1. Social media marketing (SMM) will encourage you to get best quality business and leads which will come to be therapeutic for you. By using social websites you?re going to be marketing your enterprise inside market you work in knowning that too in speedy manner. You?re going to get an improvement immediately. However, just remember to check information on social websites services proposed by a selected (Search Media Optimization) SMO Company or agency. It?s responsibility to determine the authenticity and effectiveness of services provided by SMO Company or agency.
2. Facebook marketing services offers you the advantage of taking your products and services to new markets while sitting in cool comforts in your home. You don?t have to bother about marketing your newly introduced products and services inside the untouched markets. The entire thing may occur when you successfully start running facebook marketing campaigns together with the obvious assistance of top SMO agencies. These social media marketing agencies offer around the clock technical along with other customer service to clients. There are actually really good alternatives offered to promote your internet business within few hours. Just go for a smart search.

3. An excellent and trusted Social internet marketing Agency offers services in:

a. Blogging: includes building a blog and updating it frequently.
b. Micro blogging: includes making tiny fragments of required information and sending them on sites like Twitter and Tumblr.
c. Web 2 . 0: includes posting updates about latest products/services/discounts/offers of your respective website on various social media sites.

Social media has several benefits stored for small, medium and huge scale enterprises and provides ideal results that you just cannot finish physical marketing.

Filed under: Social Media

Source: http://www.coolyourmyspace.com/social-media/how-email-marketing-services-may-help-businesses.html

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5 Life Changes That Affect Car Insurance Rates | Eric Finance

When it comes to choosing auto insurance, there are countless websites and resources devoted to picking the right policy and getting as many discounts as possible. However, it is important to remember that negotiating your policy rates doesn?t stop once you sign a contract. As your life changes, you may be entitled to further discounts ahead. Read on to learn about the five major life changes that can affect your rates for car insurance.

1. Moving To New Address

A major factor in determining your insurance rates is your geographical location. Those who live in large cities will typically have greater premiums than someone living in a rural or suburban location. While city drivers are more likely to have their cars stolen or get into accidents, rural drivers are far less likely to be in major accidents and can get discounts for having covered garages for their vehicles, something that reduces the chance of theft and of damage. As soon as you move, make sure you report it to your car insurance company in order to prevent any problems with your policy or with coverage.

2. Changing Your Place of Employment

Most people would never think to inform their auto insurance company about their change in employment status, but it can actually have a big impact on the monthly premiums you pay. If you first got your policy when driving 100 miles each day to and from work, you likely paid a premium for the higher mileage. Those who switch to part time work, telecommute from home, or retire ought to inform their insurance company right away. With fewer miles driven daily, you could receive greater discounts to your policy overall.

3. Getting Married
On the whole, married couples are considered to be more responsible and less reckless than their single counterparts. So while your marriage could bring you happiness and love, it can also bring you serious discounts on your auto insurance policy. Call up after your honeymoon to find out if your new relationship status will affect your policy rates at all.

4. Significant Birthdays

Certain driver demographics are less likely to be involved in accidents than others. The most notable demographic is those drivers who are under the age of 25. Since statistically these drivers are more likely to make claims for injuries or accidents, auto insurance companies charge them higher rates. When you turn 25, be sure to call your insurance provider and request a discount.

5. Getting Top Grades

Whether you are a teenager in high school or a student finishing your master?s degree, you can get discounts on your car insurance policy thanks to the right grades. Many insurance providers offer reduced rates to their student drivers in high school or in college who are able to show proof of a B average or higher.

Since auto insurance premiums can be quite expensive, it is up to the policy holder to keep an eye out for any discounts that could affect their monthly fees. Each of these significant life changes could alter the amount you pay for auto insurance, so stay in touch with your provider about each one.

Willie Lewis is a freelance writer who blogs about car insurance discounts. If you are in auto insurance, you can compare cheap car insurance quotes at carinsurance.org.uk to save on premiums.

Source: http://www.ericfinance.com/car-insurance-rate/

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